Martin Holst Lange, Executive Vice President for Development at Novo Nordisk, stated, These data reinforce the comprehensive set of health benefits of semaglutide, making it a strong option for healthcare professionals addressing the spectrum of metabolic and cardiovascular health. The SOUL trial confirmed the established safety and tolerability of oral semaglutide, with no new safety concerns identified and long-term safety data covering over 33 million patient years
More serious but rare adverse effects include pancreatitis, gallbladder problems, and changes in vision
The studies are usually small and test for dosing regime and toxicity levels
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However, the use of semaglutide may also lead to irreparable damage to the vagus nerve : this can cause severe side effects like gastroparesis, or stomach paralysis